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The Substance
2024
This page collects YouTube reaction videos for The Substance — first-time watches, commentaries, and reactor opinions all in one place. Subscribe to get notified when new reactions drop.
Reactions (15)
The Substance | Canadian First Time Watching | Movie Reaction | Movie Review | Movie Commentary
CineBinge
52,328 views★0.00 (3,266 ratings)
7/14/2025
THE SUBSTANCE (2024) MOVIE REACTION!! - First Time Watching! (Reupload)
Raggedy Pack
17,030 views★0.00 (835 ratings)
6/7/2025
FIRST TIME WATCHING - The Substance
Canon Event
694 views★0.00 (28 ratings)
3/21/2025
THE SUBSTANCE (2024) FIRST TIME WATCHING MOVIE REACTION AND COMMENTARY
Reel Review HQ
46,746 views★0.00 (2,699 ratings)
3/7/2025
THE SUBSTANCE (2024) Movie Reaction • Demi Moore • Dennis Quaid • DISGUSTINGLY HILARIOUS!
Moana Goes Overboard
787 views★0.00 (30 ratings)
3/1/2025
The Substance (2024) | Movie Reaction | First Time Watching | The Weirdest Creature Feature Ever
You, Me, & The Movies
41,004 views★0.00 (2,142 ratings)
2/28/2025
THE SUBSTANCE (2024) IS BAT**** CRAZY!! MOVIE REACTION!! First Time Watching | Demi Moore
Reel Rejects
147,908 views★0.00 (5,538 ratings)
2/27/2025
THE SUBSTANCE (2024) Movie Reaction! | First Time Watch | Demi Moore | Margaret Qualley
CinePals
150,723 views★0.00 (5,998 ratings)
1/24/2025
The Substance (2024) | FIRST TIME WATCHING | Movie Reaction
BissFlix
16,778 views★0.00 (970 ratings)
1/21/2025
first time watching *THE SUBSTANCE* (2024)
Jimmy Macram
2,942 views★0.00 (205 ratings)
12/28/2024
The Substance (2024) Movie REACTION | First Time Watching | Movie Review
Nikki & Steven React
179,307 views★0.00 (7,437 ratings)
12/10/2024
"The Substance (2024) Reaction & Review | Demi Moore's Bold Horror Comeback"
Southernbelle Reacts
9,221 views
11/29/2024
The Substance Movie Review!
LET’S TUNE IN
511 views★0.00 (39 ratings)
11/23/2024
THE SUBSTANCE IS INSANE! MOVIE REACTION! First Time Watching | Demi Moore | Margaret Qualley |Review
Reel Rejects
430,834 views★0.00 (14,047 ratings)
11/14/2024
THE SUBSTANCE *REACTION* FIRST TIME WATCHING!
Petty Pumpkins
126,471 views★0.00 (5,539 ratings)
10/28/2024